Ansatrienin A
Product Specifications
CAS Number
82189-03-5
Target
Others, Antifungal, Antibiotic
Related Pathways
Microbiology/Virology, Others
Bioactivity
Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis. In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM) . It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 570 nM) . Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fluorouracil , cisplatin , bleomycin , mitomycin C , and 6-mercaptopurine. It is an oxidized form of ansatrienin B .
Smiles
CO[C@@H]1CC(=O)NC2=CC(=O)C=C(CC\C=C(C)/[C@H](O)[C@@H](C)[C@H](C\C=C\C=C\C=C\1)OC(=O)[C@@H](C)NC(=O)C1CCCCC1)C2=O
Molecular Formula
C36H48N2O8
Molecular Weight
636.786
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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