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Pifithrin-? hydrobromide

Product Specifications

CAS Number

511296-88-1

Target

MDM-2/p53|||Ferroptosis|||p53

Related Pathways

Apoptosis

Purity

0.9974

Bioactivity

Pifithrin-? hydrobromide (Cyclic PFT-?) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of Y therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 ?M) .

Smiles

Br.Cc1ccc(cc1)-c1cn2c3CCCCc3sc2n1

Molecular Formula

C16H17BrN2S

Molecular Weight

349.29

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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