AAF-CMK (trifluoroacetate salt)
Product Specifications
CAS Number
184901-82-4
Target
Others|||Proteasome
Related Pathways
Others|||Proteases/Proteasome|||Ubiquitination
Bioactivity
Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides. AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 ?M. It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 ?M.
Smiles
OC(=O)C(F)(F)F.C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(=O)CCl
Molecular Formula
C18H23ClF3N3O5
Molecular Weight
453.84
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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