Crenigacestat
Product Specifications
CAS Number
1421438-81-4
Target
Gamma-secretase
Related Pathways
Proteases/Proteasome, Stem Cells, Neuroscience
Purity
0.9899
Bioactivity
Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most tumor cell lines tested. It effectively inhibits mutant Notch receptor activity and, in a xenograft tumor model, inhibits the expression of Notch-regulated genes and N1ICD cleavage in the tumor microenvironment.
Smiles
C[C@H](NC(=O)CCC(F)(F)F)C(=O)N[C@H]1c2ccccc2-c2cccnc2N(CCO)C1=O
Molecular Formula
C22H23F3N4O4
Molecular Weight
464.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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