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Crenigacestat

Product Specifications

CAS Number

1421438-81-4

Target

Gamma-secretase

Related Pathways

Proteases/Proteasome|||Stem Cells|||Neuroscience

Purity

0.9899

Bioactivity

Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most tumor cell lines tested. It effectively inhibits mutant Notch receptor activity and, in a xenograft tumor model, inhibits the expression of Notch-regulated genes and N1ICD cleavage in the tumor microenvironment.

Smiles

C[C@H](NC(=O)CCC(F)(F)F)C(=O)N[C@H]1c2ccccc2-c2cccnc2N(CCO)C1=O

Molecular Formula

C22H23F3N4O4

Molecular Weight

464.44

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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