PF-06843195
Product Specifications
CAS Number
2067281-51-8
Target
PI3K
Related Pathways
PI3K/Akt/mTOR signaling
Purity
0.9801
Bioactivity
PF-06843195 is a potent and selective PI3Kα inhibitor that binds to the active site of PI3Kα and prevents it from catalyzing the conversion of PIP2 to PIP3, thereby inhibiting the activation of AKT, with anti-tumor activity in vitro and in vivo.
Smiles
N([C@]1(CO)CN(C(OCC(F)F)=O)CC1)C=2C(F)=C(N=C(N2)N3CCOCC3)C=4C=NC(N)=NC4
Molecular Formula
C20H25F3N8O4
Molecular Weight
498.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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