NSC 12
Product Specifications
CAS Number
102586-30-1
Target
FGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis
Purity
0.9951
Bioactivity
NSC 12 is an orally active pan-FGF trap that inhibits FGF-dependent tumor cell proliferation, angiogenesis, and metastasis.NSC 12 binds FGF2 and interferes with its interaction with FGFR1, but does not affect the ability of FGF2 to bind heparin or heparan sulfate proteoglycans (HSPGs), with potential antitumor activity.NSC 12 also organizes several other FGF isoforms to form the HSPG/FGF/FGFR ternary complex.
Smiles
C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@H](CC(C(F)(F)F)(C(F)(F)F)O)O)[H])[H]
Molecular Formula
C24H34F6O3
Molecular Weight
484.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS7099286 Inquire
Recombinant Arabidopsis thaliana PRA1 family protein B6 (PRA1B6), partial
Sign In for Pricing
View Details 
orb2419781 100 µL
Vesicle docking protein p115 Rabbit Polyclonal Antibody (BF594)
Sign In for Pricing
View Details ![Mouse Monoclonal CD1e Antibody (704407) [Janelia Fluor 646]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
FAB7330J 0.1 mL
Mouse Monoclonal CD1e Antibody (704407) [Janelia Fluor 646]
Sign In for Pricing
View Details AMM06880G 0.1 mg
Polyclonal OCT6 (aa192-204) Antibody (internal region)
Sign In for Pricing
View Details 35-1786-50 50 μL
Polyclonal Antibody to LPAM-1 (Integrin Alpha4, CD49d)
Sign In for Pricing
View Details