NSC 12
Product Specifications
CAS Number
102586-30-1
Target
FGFR
Related Pathways
Tyrosine Kinase/Adaptors|||Angiogenesis
Purity
0.9951
Bioactivity
NSC 12 is an orally active pan-FGF trap that inhibits FGF-dependent tumor cell proliferation, angiogenesis, and metastasis.NSC 12 binds FGF2 and interferes with its interaction with FGFR1, but does not affect the ability of FGF2 to bind heparin or heparan sulfate proteoglycans (HSPGs), with potential antitumor activity.NSC 12 also organizes several other FGF isoforms to form the HSPG/FGF/FGFR ternary complex.
Smiles
C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@H](CC(C(F)(F)F)(C(F)(F)F)O)O)[H])[H]
Molecular Formula
C24H34F6O3
Molecular Weight
484.52
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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