Pirtobrutinib
Product Specifications
CAS Number
2101700-15-4
Target
BTK
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis
Purity
0.9994
Bioactivity
Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to tumor regression in BTK-dependent lymphoma tumors in mouse xenograft models. Furthermore, Pirtobrutinib exhibits remarkable selectivity for BTK, with more than a 300-fold difference compared to 370 other kinases tested. Notably, at a concentration of 1 μM, Pirtobrutinib demonstrates no significant inhibition of non-kinase off-targets.
Smiles
COc1ccc(F)cc1C(=O)NCc1ccc(cc1)-c1nn([C@@H](C)C(F)(F)F)c(N)c1C(N)=O
Molecular Formula
C22H21F4N5O3
Molecular Weight
479.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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