XStAx-VHLL

Product Specifications

Target

PROTACs|||APC/C|||Wnt/beta-catenin

Related Pathways

Cytoskeletal Signaling|||Stem Cells|||PROTAC|||Cell Cycle/Checkpoint

Bioactivity

Selective peptide-based ?-catenin Degrader. Comprises a ?-catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. Reduces ?-catenin levels in HEK293T cells and colorectal cancer cell lines. Selectively degrades ?-catenin over other Wnt signaling pathway components. Inhibits tumor growth in APCmin/+ mice, with constitutively active Wnt signaling, and reduces survival of patient-derived colorectal cancer cell organoids.