XStAx-VHLL
Product Specifications
Target
PROTACs|||APC/C|||Wnt/beta-catenin
Related Pathways
Cytoskeletal Signaling|||Stem Cells|||PROTAC|||Cell Cycle/Checkpoint
Bioactivity
Selective peptide-based ?-catenin Degrader. Comprises a ?-catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. Reduces ?-catenin levels in HEK293T cells and colorectal cancer cell lines. Selectively degrades ?-catenin over other Wnt signaling pathway components. Inhibits tumor growth in APCmin/+ mice, with constitutively active Wnt signaling, and reduces survival of patient-derived colorectal cancer cell organoids.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
