What is the catalog number for LC-2?

The catalog number for LC-2 is T36256.

What sizes are available for LC-2?

LC-2 is available in the following size(s): 50 mg, 1 mg, 5 mg.

How many pack sizes does LC-2 come in?

LC-2 is available in 3 different pack sizes.

LC-2 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures LC-2?

LC-2 is manufactured by Molfinity.

What is the estimated delivery time for LC-2?

Estimated delivery time for LC-2 is approximately 10 business day(s), depending on your location.

LC-2

Product Specifications

CAS Number

2502156-03-6

Target

PROTACs, Ras, Kras

Related Pathways

PROTAC, GPCR/G Protein, MAPK

Purity

0.98

Bioactivity

LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is a PROTAC that covalently binds KRAS G12C with MRTX849 and recruits the E3 ligase, VH, to induce a rapid and sustained degradation of KRAS G12C. LC-2 inhibits MAPK signaling in pure and heterozygous KRAS G12C cell lines.

Smiles

Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCCN2CCC[C@H]2COc2nc3CN(CCc3c(n2)N2CCN([C@@H](CC#N)C2)C(=O)C(F)=C)c2cccc3cccc(Cl)c23)C(C)(C)C)cc1