SJF 8240
Product Specifications
CAS Number
2230821-68-6
Target
PROTACs|||c-Met/HGFR|||Others
Related Pathways
PROTAC|||Tyrosine Kinase/Adaptors|||Others
Bioactivity
C-MET degrader. Comprises MET inhibitor foretinib (GSK 1363089) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours in vitro. Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66.7 nM) . Also degrades exon-14-deleted c-MET in Hs746T cells.
Smiles
COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCOCCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C|@:75|
Molecular Formula
C58H65F2N7O11S
Molecular Weight
1106.25
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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