SJF 1528
Product Specifications
CAS Number
2230821-38-0
Target
Others, PROTACs, EGFR
Related Pathways
Tyrosine Kinase/Adaptors, PROTAC, Angiogenesis, JAK/STAT signaling, Others
Bioactivity
Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells) . Also degrades HER2. Comprises the EGFR inhibitor lapatinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells) .
Smiles
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOc2ccc(cc2)-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)C(C)(C)C)cc1 |@:67|
Molecular Formula
C55H57ClFN7O8S
Molecular Weight
1030.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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