Arecaidine propargyl ester (hydrobromide)

Arecaidine propargyl ester is an agonist of M2muscarinic acetylcholine receptors (mAChRs) .1It selectively binds to M2over M1, M3, M4, and M5mAChRs in CHO cells expressing the human receptors (Kis = 0.0871, 1.23, 0.851, 0.977, and 0.933 μM, respectively) . Arecaidine propargyl ester induces contractions in isolated guinea pig atrium (pD2= 8.67) . It induces apoptosis and the production of reactive oxygen species (ROS) in U87 and U251 glioblastoma cells when used at a concentration of 100 μM.2Arecaidine propargyl ester decreases mean arterial blood pressure in normotensive cats (ED25= 1.9 nmol/kg) .3It is toxic to house flies (Musca) when administered at a dose of 75 μg/fly.4