17R (18S) -EpETE
Product Specifications
CAS Number
725246-18-4
Target
Calcium Channel, Others
Related Pathways
Membrane transporter/Ion channel, Metabolism, Others
Bioactivity
17R (18S) -EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R (18S) -EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium current amplitude by 15-fold in isolated rat cerebral artery vascular smooth muscle cells (VSMCs) at +60 mV when used at a concentration of 50 nM.2It has negative chronotropic effects in isolated neonatal rat cardiomyocytes (NRCMs; EC50= ~1-2 nM) and prevents calcium-induced increases in the spontaneous beating of NRCMs.3,4
Smiles
CC[C@@H]1O[C@@H]1C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
Molecular Formula
C20H30O3
Molecular Weight
318.457
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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