CAY10406
Product Specifications
CAS Number
2108603-03-6
Target
Others, Caspase
Related Pathways
Others, Proteases/Proteasome, Apoptosis
Bioactivity
CAY10406 is a trifluoromethyl analog of an isatin sulfonamide compound that selectively inhibits caspases 3 and 7. The non-trifluoromethyl compound exhibits Ki values of 1.2 nM and 6 nM for caspases 3 and 7, respectively. For all of the other caspases tested, it is 100 to 1,000 times less potent. Caspases 3 and 7 are 'effector caspases' that are downstream from the initiating steps of apoptosis, and are implicated in the main proteolytic processing of the apoptotic signal. No data is currently available for caspase inhibition by CAY10406.
Smiles
C(N1C=2C(=CC(S(=O)(=O)N3[C@H](COC4=CC=C(C(F)(F)F)C=C4)CCC3)=CC2)C(=O)C1=O)C5=CC=CC=C5
Molecular Formula
C27H23F3N2O5S
Molecular Weight
544.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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