Ivosidenib
Product Specifications
CAS Number
1448347-49-6
Target
Isocitrate Dehydrogenase (IDH), Dehydrogenase
Related Pathways
Metabolism
Purity
>99.99%
Bioactivity
Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. It specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of the oncometabolite 2-hydroxyglutarate (2 hG), which may induce cellular differentiation and inhibit cellular proliferation in IDH1-expressing tumor cells.
Smiles
Fc1cncc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N
Molecular Formula
C28H22ClF3N6O3
Molecular Weight
582.96
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
EK341355 96 Well
Human Itgam/CD11b (Integrin alpha-M) ValidElisa Kit
Sign In for Pricing
View Details 
MBS2613801-01 48 Well
Bovine Interleukin-12 receptor subunit beta-2 (IL12RB2) ELISA Kit
Sign In for Pricing
View Details MBS2613801-02 96 Well
Bovine Interleukin-12 receptor subunit beta-2 (IL12RB2) ELISA Kit
Sign In for Pricing
View Details MBS2613801-03 5x 96 Well
Bovine Interleukin-12 receptor subunit beta-2 (IL12RB2) ELISA Kit
Sign In for Pricing
View Details MBS2613801-04 10x 96 Well
Bovine Interleukin-12 receptor subunit beta-2 (IL12RB2) ELISA Kit
Sign In for Pricing
View Details