8-iso Prostaglandin E2
Product Specifications
CAS Number
27415-25-4
Target
Others, Prostaglandin Receptor
Related Pathways
GPCR/G Protein, Immunology/Inflammation, Others
Bioactivity
8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 μM, respectively. When infused into the renal artery of the rat at a concentration of 4 μg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.
Smiles
CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@H]1C\C=C/CCCC(O)=O
Molecular Formula
C20H32O5
Molecular Weight
352.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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