14,15-EE-5 (Z) -E
Product Specifications
CAS Number
519038-92-7
Target
Others|||Endogenous Metabolite
Related Pathways
Others|||Metabolism
Bioactivity
Epoxyeicosatrienoic acids (EETs), such as 11 (12) -EET and 14 (15) -EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-5 (Z) -E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle. Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5 (Z) -E at a concentration of 10 ?M. 14,15-EE-5 (Z) -E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation.
Smiles
CCCCC[C@@H]1O[C@@H]1CCCCCCC\C=C/CCCC(O)=O
Molecular Formula
C20H36O3
Molecular Weight
324.505
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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