Evofosfamide
Product Specifications
CAS Number
918633-87-1
Target
Apoptosis
Related Pathways
Apoptosis
Purity
0.9975
Bioactivity
Evofosfamide (TH-302) is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM) conjugated with 2-nitroimidazole, possessing potential antineoplastic activity. Under hypoxic conditions, typical of hypoxic tumors, the 2-nitroimidazole moiety is reduced, releasing the DNA-alkylating Br-IPM moiety, which induces intra- and inter-strand DNA crosslinks that inhibit DNA replication and cell division, potentially causing apoptosis in tumor cells. The inactive form of the prodrug remains stable under normoxic conditions, which may reduce systemic toxicity.
Smiles
Cn1c(COP(=O)(NCCBr)NCCBr)cnc1[N+]([O-])=O
Molecular Formula
C9H16Br2N5O4P
Molecular Weight
449.04
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
038951 200 µL
NFYC, NT (NFYC, Nuclear transcription factor Y subunit gamma, CAAT box DNA-binding protein subunit C, Nuclear transcription factor Y subunit C, Transactivator HSM-1/2)
Sign In for Pricing
View Details 
MBS1377278-01 0.02 mg (E-Coli)
Recombinant Bradyrhizobium japonicum Orotidine 5'-phosphate decarboxylase (pyrF)
Sign In for Pricing
View Details MBS1377278-02 0.1 mg (E-Coli)
Recombinant Bradyrhizobium japonicum Orotidine 5'-phosphate decarboxylase (pyrF)
Sign In for Pricing
View Details