BMP-22
Product Specifications
CAS Number
1306684-90-1
Target
Others|||PDE
Related Pathways
Metabolism|||Others
Bioactivity
BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM) . It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 ?M. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine in vitro in a concentration-dependent manner. It inhibits LPC-dependent MM1 cell invasion of a human umbilical vein endothelial cell (HUVEC) monolayer. BMP-22 (0.5 mg/kg per day) decreases the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis.
Smiles
C(CCCCCCCCCCCCCC)C1=CC=C(CP(=O)(O)O)C=C1
Molecular Formula
C22H39O3P
Molecular Weight
382.52
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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