Thiocoraline

Thiocoraline is a depsipeptide and DNAbis-intercalator originally isolated fromMicromonosporawith antibacterial and anticancer activities.1,2It is active against the Gram-positive bacteriaS. aureus, B. subtilis, andM. luteus (MICs = 0.05, 0.05, and 0.03 ?g/ml, respectively) but not Gram-negativeE. coli, K. pneumoniae, orP. aeruginosa (MICs = >100 ?g/ml for all) .1Thiocoraline inhibits RNA and DNA polymerase and thymidylate synthase (IC50s = 6, 6, and 15 ?g/ml, respectively), as well as RNA and DNA synthesisin vitro (IC50s = 0.008 and 0.4 ?g/ml, respectively) . It is cytotoxic to P388, A549, HT-29, and MEL-28 cancer cells (IC50s = 0.002, 0.002, 0.01, and 0.002 ?g/ml, respectively) .