LH1307
Product Specifications
CAS Number
2375720-38-8
Target
Others, PD-1/PD-L1
Related Pathways
Others, Immunology/Inflammation, Apoptosis, Cell Cycle/Checkpoint
Bioactivity
LH1307 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 3 nM in a homologous time-resolved fluorescence (HTRF) assay.1 It increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1 (EC50s = 79 and 763 nM, respectively, in reporter assays) .
Smiles
CC(=O)NCCNCc1cc(C)c(OCc2cccc(c2C)-c2cccc(COc3cc(OCc4cncc(c4)C#N)c(CNCCNC(C)=O)cc3C)c2C)cc1OCc1cncc(c1)C#N
Molecular Formula
C54H58N8O6
Molecular Weight
915.108
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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