Sodium dichloroacetate
Product Specifications
CAS Number
2156-56-1
Target
PDK, ROS, Reactive Oxygen Species, Apoptosis, Dehydrogenase, Na-K-Cl cotransporter
Related Pathways
Membrane transporter/Ion channel, Metabolism, PI3K/Akt/mTOR signaling, NF-κB, Apoptosis, Immunology/Inflammation
Purity
0.9987
Bioactivity
Sodium dichloroacetate (BCA), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth.
Smiles
C(C(=O)[O-])(Cl)Cl.[Na+]
Molecular Formula
C2HCl2NaO2
Molecular Weight
150.92
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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