Erastin2
Product Specifications
CAS Number
1695533-44-8
Target
Ferroptosis
Related Pathways
Apoptosis
Purity
0.9963
Bioactivity
Erastin2 is a ferroptosis inducer and inhibitor of the system xc- cystine/glutamate transporter.[1][2] It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 µM) and induces cell death in HAP1 cells at 5 µM, an effect blocked by ferrostatin-1 or deferoxamine.[1][2] Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 µM), an effect blocked by β-mercaptoethanol (EC50 > 20 µM) .[3] Additionally, it increases lipid peroxidation in HT-1080 cells at 1 µM.
Smiles
CC(C)Oc1ccc(cc1-n1c(CN2CCN(CC2)C(=O)COc2ccc(Cl)cc2)nc2ccccc2c1=O)-c1ccccc1
Molecular Formula
C36H35ClN4O4
Molecular Weight
623.14
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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