Ent-Prostaglandin E2
Product Specifications
CAS Number
65085-69-0
Target
Others|||Prostaglandin Receptor
Related Pathways
GPCR/G Protein|||Immunology/Inflammation|||Others
Bioactivity
Enzymatically-derived prostaglandin E2 (PGE2) is an optically pure compound whereas PGE2 derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture. Ent-PGE2 is the opposite enantiomer of PGE2. Significant amounts of racemic PGE2 (rac-PGE2) are generated in vitro and in vivo in settings of oxidative stress via the isoprostane pathway. A proposed mechanism for the formation of rac-PGE2 involves the base catalyzed equilibration from 15-E2t-isoprostane (8-iso-PGE2), generated from the 15-H2t-isoprostane endoperoxide.
Smiles
CCCCC[C@@H](O)\C=C\[C@@H]1[C@@H](O)CC(=O)[C@H]1C\C=C/CCCC(O)=O
Molecular Formula
C20H32O5
Molecular Weight
352.471
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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