Ent-8-iso-15 (S) -Prostaglandin F2α
Product Specifications
CAS Number
214748-66-0
Target
Others, Endogenous Metabolite
Related Pathways
Others, Metabolism
Bioactivity
Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have potent biological activity. ent-8-iso-15 (S) -Prostaglandin F2α (ent-8-iso-15 (S) -PGF2α) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 15 and 24 nM, respectively. This isoprostane is about ten-fold more potent than 8-iso-PGF2α in a whole blood platelet aggregation inhibition assay.
Smiles
C(/C=C\CCCC(O)=O)[C@@H]1[C@H](/C=C/[C@H](CCCCC)O)[C@@H](O)C[C@H]1O
Molecular Formula
C20H34O5
Molecular Weight
354.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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