MitoPBN
Product Specifications
CAS Number
652968-37-1
Target
Others, Endogenous Metabolite
Related Pathways
Others, Metabolism
Bioactivity
MitoPBN is a mitochondria-targeted antioxidant that accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect blocked by the addition of the mitochondrial membrane potential uncoupler FCCP. MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 at a concentration of 250 nM in vitro, but does not react with superoxide. It traps hydroxyl (IC50 = ~77 μM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria.
Smiles
[Br-].CC(C)(C)N(=O)=Cc1ccc(OCCCC[P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
Molecular Formula
C33H37BrNO2P
Molecular Weight
590.542
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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