PAR2 (1-6) amide (human) (trifluoroacetate salt)

PAR2 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR2 and residues 37-42 of the full-length sequence.1It binds to NCTC 2544 cells expressing human PAR2 (Ki= 9.64 ?M in a radioligand binding assay) and induces calcium mobilization in the same cells (EC50= 0.075 ?M) .2PAR2 (1-6) amide (100 ?M) reduces colony formation of A549 lung cancer cells.1It induces superoxide production and degranulation in isolated human eosinophils when used at a concentration of 500 ?M.3PAR2 (1-6) amide (5 ?mol/kg) induces tear secretion in rats when used in combination with amastatin .4