D-myo-Inositol-1,4,6-triphosphate (sodium salt)

D-myo-Inositol-1,4,6-phosphate (Ins (1,4,6) -P3) is a member of the inositol phosphate (InsP) family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins (1,4,5) -P3, is a second messenger produced in cells by phospholipase C (PLC) -mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins (1,4,5) -P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins (1,4,6) -P3 (tested as the meso compound) is 9-fold less potent than Ins (1,4,5) -P3 at initiating Ca2+ release when injected into Xenopus oocytes.