NVS-PAK1-C
Product Specifications
CAS Number
2250019-95-3
Target
Others, PAK
Related Pathways
Others, Cytoskeletal Signaling
Bioactivity
NVS-PAK1-1 is a potent allosteric inhibitor of PAK1 with an IC 50 of 5 nM for dephosphorylated PAK1 and 6 nM for phosphorylated PAK1 as assessed. Inhibition is ATP-competitive, most likely due to indirect competition due to incompatibility of ATP binding with the DFG-out binding conformation of the allosteric compound. NVS-PAK1-1 has an IC50 of 270 nM against dephosphorylated PAK2 and 720 nM against phosphorylated PAK2 respectively [1].
Smiles
C(C(F)F)N1C=2C(C(N[C@@H]3CN(C(N(C)C)=O)CC3)=NC=4C1=CC=C(F)C4)=CC(Cl)=CC2
Molecular Formula
C22H23ClF3N5O
Molecular Weight
465.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
