Paraherquamide A
Product Specifications
CAS Number
77392-58-6
Target
Others
Related Pathways
Others
Bioactivity
Paraherquamide A is a mycotoxin anthelmintic originally isolated from P. paraherquei. It binds to acetylcholine receptors (IC50 = 0.5 nM for head homogenates of M. domestica) and acts as an antagonist. Paraherquamide A is toxic to C. elegans (LD50 = 2.5 μg/ml) and effective against T. colubriformis infection in gerbils when used at doses ranging from 0.39 to 200 mg/kg. It is toxic to mice (LD50 = 14.9 mg/kg) .
Smiles
CN1C(=O)[C@]23C[C@H]4C(C)(C)[C@@]5(C[C@]14CN2CC[C@@]3(C)O)C(=O)Nc1c5ccc2OC(C)(C)C=COc12
Molecular Formula
C28H35N3O5
Molecular Weight
493.604
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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