What is the catalog number for JAK2-IN-7?

The catalog number for JAK2-IN-7 is T35900.

What sizes are available for JAK2-IN-7?

JAK2-IN-7 is available in the following size(s): 1 mg, 5 mg, 1 mL - 10 mM (in DMSO), 10 mg, 25 mg, 50 mg, 100 mg.

How many pack sizes does JAK2-IN-7 come in?

JAK2-IN-7 is available in 7 different pack sizes.

Is JAK2-IN-7 in stock?

JAK2-IN-7 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures JAK2-IN-7?

JAK2-IN-7 is manufactured by Molfinity.

What is the estimated delivery time for JAK2-IN-7?

Estimated delivery time for JAK2-IN-7 is approximately 10 business day(s), depending on your location.

JAK2-IN-7

Product Specifications

CAS Number

2593402-36-7

Target

JAK, FLT, Apoptosis

Related Pathways

Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, Stem Cells, JAK/STAT signaling, Angiogenesis, Apoptosis

Purity

0.9954

Bioactivity

JAK2-IN-7, a selective inhibitor targeting Janus Kinase 2 (JAK2), exhibits inhibitory concentrations (IC50) of 3 nM for JAK2, 11.7 nM for SET-2 cells, and 41 nM for Ba/F3 V617F cells, indicative of its potency and selectivity. This compound demonstrates more than 14-fold selectivity against JAK1, JAK3, and FLT3, underlining its specificity. JAK2-IN-7 effectively induces cell cycle arrest at the G0/G1 phase and promotes apoptosis in tumor cells, manifesting significant antitumor activities [1].