JAK2-IN-7
Product Specifications
CAS Number
2593402-36-7
Target
JAK|||FLT|||Apoptosis
Related Pathways
Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic|||Stem Cells|||JAK/STAT signaling|||Angiogenesis|||Apoptosis
Purity
0.9954
Bioactivity
JAK2-IN-7, a selective inhibitor targeting Janus Kinase 2 (JAK2), exhibits inhibitory concentrations (IC50) of 3 nM for JAK2, 11.7 nM for SET-2 cells, and 41 nM for Ba/F3 V617F cells, indicative of its potency and selectivity. This compound demonstrates more than 14-fold selectivity against JAK1, JAK3, and FLT3, underlining its specificity. JAK2-IN-7 effectively induces cell cycle arrest at the G0/G1 phase and promotes apoptosis in tumor cells, manifesting significant antitumor activities [1].
Smiles
C(/C=C/CN(C)C)(=O)N1CC=2C(=CC(NC=3N=C(C(C)=CN3)C4=CN(C(C)C)N=C4)=CC2)CC1
Molecular Formula
C26H33N7O
Molecular Weight
459.59
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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