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T-5342126

Product Specifications

CAS Number

956507-49-6

Target

Others, TLR

Related Pathways

Immunology/Inflammation, Others

Bioactivity

T-5342126 is a toll-like receptor 4 (TLR4) antagonist that reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 = 27.8 μM) and decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 μM, respectively) . T-5342126 (82 mg/kg) also reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.

Smiles

C(N1C(C)=C(CN(CC(COC2=CC=C(OCC)C=C2)O)C)C(C)=N1)C3=C(Cl)C=CC=C3

Molecular Formula

C25H32ClN3O3

Molecular Weight

457.99

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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