ZLY032
Product Specifications
CAS Number
2314465-67-1
Target
PPAR|||Others
Related Pathways
Metabolism|||Others|||DNA Damage/DNA Repair
Bioactivity
ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor ? (PPAR?; EC50= 102 nM in a reporter assay) .1It is selective for FFAR1 and PPAR? over PPAR? and PPAR? (EC50s = >10 ?M for both) . ZLY032 (40 mg/kg, twice per day) reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in theob/obmouse model of metabolic disease.2It reduces hepatic steatosis and plasma alanine transaminase (ALT) and aspartate aminotransferase (AST) levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine and choline-deficient diet at the same dose.
Smiles
C(C(O)=O)[C@H]1C=2C(=CC(OCC=3SC(=NC3C)C4=CC=C(C(F)(F)F)C=C4)=CC2)OC1
Molecular Formula
C22H18F3NO4S
Molecular Weight
449.44
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
L1325-70A-ML550 100 µL
LECT1, CT (Chondromodulin-1, Chondromodulin-I, ChM-I, Leukocyte Cell-Derived Chemotaxin 1, CHMI) (MaxLight 550) discontinued
Ask
View Details