Swinholide A
Product Specifications
CAS Number
95927-67-6
Target
Antifungal
Related Pathways
Microbiology/Virology
Bioactivity
Swinholide A is a polyketone compound that can be extracted from sponges and binds to actin to dimerize actin with Kd of about 50 nM. Swinholide A is a cytotoxin that stabilizes actin dimers and severs actin filaments. Swinholide A has antifungal activity and can damage the actin cytoskeleton of cells.
Smiles
[H][C@]12CC=C[C@@]([H])(C[C@@H](O)CC=C(C)C=CC(=O)O[C@]([H])([C@@H](C)[C@@H](O)[C@@H](C)CC[C@H]3C[C@@H](C[C@H](C)O3)OC)[C@@H](C)[C@H](O)C[C@H](O)[C@H](C)[C@H](C[C@]3([H])CC=C[C@@]([H])(C[C@@H](O)CC=C(C)C=CC(=O)O[C@]([H])([C@@H](C)[C@@H](O)[C@@H](C)CC[C@H]4C[C@@H](C[C@H](C)O4)OC)[C@@H](C)[C@H](O)C[C@H](O)[C@H](C)[C@H](C1)OC)O3)OC)O2 |c:3,53|
Molecular Formula
C78H132O20
Molecular Weight
1389.87
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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