HC Toxin
Product Specifications
CAS Number
83209-65-8
Target
Apoptosis, Others, HDAC
Related Pathways
Others, Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair
Bioactivity
HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM) . Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.
Smiles
C[C@H]1NC(=O)[C@H](CCCCCC(=O)[C@@H]2CO2)NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O
Molecular Formula
C21H32N4O6
Molecular Weight
436.509
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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