Emestrin
Product Specifications
CAS Number
97816-62-1
Target
Others|||Antibacterial
Related Pathways
Others|||Microbiology/Virology
Bioactivity
Emestrin, a mycotoxin originally isolated from *E. striata*, exhibits antimicrobial, immunomodulatory, and cytotoxic activities. It is effective against fungi *C. albicans* and *C. neoformans*, and bacteria *E. coli*, *S. aureus*, and methicillin-resistant *S. aureus* (MRSA; IC50s = 3.94, 0.6, 2.21, 4.55, and 2.21 ?g/ml, respectively) . Emestrin acts as a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50 = 5.4 ?M in a radioligand binding assay using isolated human monocytes) . At 0.1 ?g/ml, it induces apoptosis in HL-60 cells and causes necrosis in heart, thymus, and liver tissues in mice at doses of 18-30 mg/kg.
Smiles
[H][C@@]12C3OC(=O)c4ccc(OC)c(Oc5cc(ccc5O)[C@H](O)C56SSC([C@H](O)C1=COC=C3)(N2C5=O)C(=O)N6C)c4
Molecular Formula
C27H22N2O10S2
Molecular Weight
598.6
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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