Trypacidin

Trypacidin is a fungal metabolite originally isolated fromA. fumigatus.1It is active againstB. subtilisandM. bovis (MICs = 12.5 and 1.25 μg/ml, respectively), as well asT. cruziandT. gondii (MICs = 5-10 and 10-20 μg/ml, respectively) .1,2It reduces viability and induces lysis of A549 human lung cancer cells (IC50s = 7.4 μM for both) .3Trypacidin increases survival in a mouse model ofT. gondiiinfection when administered in six doses of 12.5 mg/kg each.1