Gliovirin

Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum (MIC = 60 ng/ml) and the parasiteT. brucei brucei (IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani, P. omnivorum, T. basicola, R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis, P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decreases phorbol 12-myristate 13-acetate (TPA) - and ionomycin-induced increased expression of COX-2 (IC50= 1 μM) and protein levels of IL-2 in Jurkat cells (IC50= 5.2 μM) .1