FR900098 (sodium salt)
Product Specifications
CAS Number
73226-73-0
Target
Parasite|||Others|||Antibiotic
Related Pathways
Others|||Microbiology/Virology
Bioactivity
FR900098 is a derivative of fosmidomycin that has antimalarial activity (IC50s = 170, 170, and 90 nM for HB3, A2, and Dd2 P. falciparum strains, respectively) . FR900098 inhibits DOXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis, in vitro in a dose-dependent manner. FR900098 (>10 mg/kg, i.p.) eradicated P. vinckei parasites within four days in mice.
Smiles
[Na].CC(=O)N(O)CCCP(O)(O)=O
Molecular Formula
C5H12NNaO5P
Molecular Weight
220.117
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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