Neoaureothin
Product Specifications
CAS Number
59795-94-7
Target
Antibacterial, Others
Related Pathways
Others, Microbiology/Virology
Bioactivity
Neoaureothin, a bacterial metabolite found in Streptomyces, is an androgen receptor (AR) antagonist that inhibits dihydrotestosterone (DHT) binding to ARs (IC50 = 13 μM) and DHT-induced prostate-specific antigen expression in LNCaP cells (IC50 = 1.75 nM) . It is cytotoxic to A549, HCT116, and HepG2 cells (IC50s = 34.3, 47, and 37.2 μg/ml, respectively), exhibits nematocidal activity against the pine wood nematode B. xylophilus (LC50 = 0.84 μg/ml), and increases survival of P. densiflora trees inoculated with B. xylophilus.
Smiles
COc1oc([C@H]2C\C(CO2)=C\C(\C)=C\C(\C)=C\C(\C)=C\c2ccc(cc2)N(=O)=O)c(C)c(=O)c1C
Molecular Formula
C28H31NO6
Molecular Weight
477.557
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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