2'2'-cGAMP (sodium salt)
Product Specifications
CAS Number
1465774-27-9
Target
Others|||Endogenous Metabolite|||STING|||IFNAR
Related Pathways
Others|||Immunology/Inflammation|||Metabolism
Bioactivity
2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes , which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2'2-cGAMP shows weaker binding to STING than 2'3'-cGAMP but binds more strongly than 3'3'-cGAMP , cyclic di-GMP , or 3'2'-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 ?M, respectively) . Despite weaker binding, 2'2'-cGAMP induces IFN-? production in the same concentration range as 2'3'-cGAMP (EC50s = 15.8 and 19.4 nM, respectively, in L929 cells) .
Smiles
[H][C@]12COP(O)(=O)O[C@@]3([H])[C@@H](O[C@]([H])(COP(O)(=O)O[C@@]([H])([C@@H](O1)n1cnc4c(N)ncnc14)C2O)[C@H]3O)n1cnc2c1[nH]c(N)nc2=O
Molecular Formula
C20H24N10O13P2
Molecular Weight
674.417
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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