4-oxo-27-TBDMS Withaferin A
Product Specifications
CAS Number
1214886-31-3
Target
Apoptosis|||Others
Related Pathways
Others|||Apoptosis
Bioactivity
4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 ?M) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 ?M) . It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 ?M) . 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.
Smiles
[H][C@@]12C[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)[C@@]5([H])CC(C)=C(CO[Si](C)(C)C(C)(C)C)C(=O)O5)[C@@]4(C)CC[C@]3([H])[C@@]3(C)C(=O)C=CC(=O)[C@@]13O2|c:44,t:17|
Molecular Formula
C34H50O6Si
Molecular Weight
582.853
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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