SHP099
Product Specifications
CAS Number
1801747-42-1
Target
PERK, Phosphatase
Related Pathways
Apoptosis, Metabolism
Purity
0.994
Bioactivity
SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM) . SHP099 shows dose-dependent pathway inhibition and antitumor activity in xenograft models.
Smiles
CC1(N)CCN(CC1)c1cnc(c(N)n1)-c1cccc(Cl)c1Cl
Molecular Formula
C16H19Cl2N5
Molecular Weight
352.26
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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