SHS4121705
Product Specifications
CAS Number
2379550-82-8
Target
Others|||Mitochondrial Metabolism
Related Pathways
Others|||Metabolism
Bioactivity
SHS4121705 is an orally bioavailable mitochondrial uncoupler.1It increases oxygen consumption rate in L6 rat myoblast cells with an EC50value of 4.3 ?M. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis, liver triglyceride levels, and plasma alanine aminotransferase (ALT) levels in Stelic animal model (STAM) mice, a model of non-alcoholic steatohepatitis (NASH) .
Smiles
N(C1=NC=2C(=NC1=O)NON2)C3=CC=C(OC(F)(F)F)C=C3
Molecular Formula
C11H6F3N5O3
Molecular Weight
313.19
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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