Dapagliflozin-3-O-?-D-Glucuronide
Product Specifications
CAS Number
1351438-75-9
Target
Others|||Endogenous Metabolite
Related Pathways
Others|||Metabolism
Bioactivity
Dapagliflozin-3-O-?-D-glucuronide is a metabolite of dapagliflozin . Dapagliflozin is a first generation selective sodium glucose cotransporter (SGLT) 2 inhibitor that blocks glucose transport.[1] Dapagliflozin is metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A9 to dapagliflozin-3-O-?-D-glucuronide, which is 2,600-fold less potent than the parent compound with regard to SGLT2 inhibition.[2]
Smiles
O[C@H]1[C@@H](O[C@H](CO)[C@@H](O)[C@@H]1O[C@@H]2O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]2O)C3=CC(CC4=CC=C(OCC)C=C4)=C(Cl)C=C3
Molecular Formula
C27H33ClO12
Molecular Weight
585
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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