Migrastatin
Product Specifications
CAS Number
314245-65-3
Target
Others|||Calcium Channel|||AChR
Related Pathways
Metabolism|||Membrane transporter/Ion channel|||Others|||Neuroscience
Bioactivity
Migrastatin is a bacterial metabolite that has been found inStreptomyceswith antimuscarinic and anticancer activities.1,2It binds to M1-5muscarinic acetylcholine receptors (Kis = >200, 200, 31, 43, and >200 ?M, respectively) and inhibits calcium mobilization induced by carbamoylcholine in SK-N-SH cells (IC50= 28 ?M), as well as in primary rat bladder smooth muscle cells.1Migrastatin inhibits the migration of EC17 esophageal cancer cells in a wound healing assay (IC50= 10 ?g/ml) and 4T1 mouse mammary carcinoma cells in a chamber cell migration assay (IC50= 29 ?M) .2It enhances cytotoxicity induced by vinblastine in vincristine-resistant P388/VCR cells.3
Smiles
[H][C@@]1(OC(=O)\C=C/CC\C=C/[C@H](OC)[C@@H](O)[C@H](C)\C=C1/C)[C@H](C)C(=O)CCCC1CC(=O)NC(=O)C1|c:5,9,t:18|
Molecular Formula
C27H39NO7
Molecular Weight
489.609
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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